Mesotherapy in North Cyprus

The mesotherapy cocktail comprises four main families of ingredients that vary according to the target indication. Knowing exactly what is being injected is your right as a patient. All cocktail products used at Nis Clinic are CE-marked, sourced from manufacturers with traceable batch numbers, and the label on the ampoule is shown to any patient who requests it.

• Hyaluronic acid (HA): Non-cross-linked, low-viscosity form. It retains moisture within the skin, increases tissue hydration and stimulates fibroblast cells towards collagen production. This is the key molecule in biorevitalisation.
• Vitamin complex: B-group vitamins (B1, B2, B3, B5, B6, B8), C, E and K. Supports cellular metabolism and reduces oxidative stress. Vitamin C is also essential at the enzymatic stage of collagen synthesis.
• Amino acids: Glycine, lysine, proline and arginine — the structural building blocks of collagen and elastin. The aim is to deliver the raw material for the skin matrix directly to the cell.
• Peptides and growth factor analogues: Found in newer-generation cocktails. They modulate intercellular signalling pathways to support tissue renewal.
• Minerals and coenzymes: Zinc, copper, selenium and coenzyme Q10. Antioxidant and enzymatic support.
• Additional ingredients for hair indications: Biotin, dexpanthenol, copper peptides and, in some products, procaine. These support the vascular network around the follicle and the hair growth cycle.

Body (localised) mesotherapy cocktails contain substances claimed to stimulate fat cell metabolism: phosphatidylcholine, L-carnitine, caffeine, theophylline and artichoke extract. The evidence for the effect of these components on cellulite is limited; we explain this in detail below.

At Nis Clinic we avoid "miracle new blend" claims. We favour formulations with a stronger evidence base that have been established in clinical use for some time. The product recommended and its full composition are shared with you in writing at consultation.

Mesotherapy should not be understood as a single application; it is delivered across three different areas, with different protocols and different realistic expectations.

1) Face — Biorevitalisation

The skin's natural production of collagen, elastin and hyaluronic acid declines with age. Facial mesotherapy delivers HA, vitamins and amino acids directly into the skin matrix, aiming to support luminosity, tissue elasticity and hydration of fine lines. It does not create instant volume like dermal filler; it improves skin quality gradually and cumulatively. Patients aged 25–45 who have not yet developed deep static lines tend to see the most noticeable benefit. In patients over 50, mesotherapy alone is usually insufficient — it is combined with filler, thread lift or surgical facelift.

2) Hair — Anti-Telogen Mesotherapy

Used for androgenetic alopecia (male- or female-pattern hair loss), telogen effluvium (shedding triggered by stress or medical conditions) and fine, weak hair structure. The cocktail injected into the scalp supports the vascular network around the follicle and the hair growth cycle; the aim is to reduce shedding rates and increase the thickness of existing hair shafts.

One important caveat: hair mesotherapy is not a standalone treatment for hair loss. Androgenetic alopecia requires a multi-modal approach — mesotherapy, microtrichological assessment (follicle analysis under dermoscopy), PRP, medical treatments such as finasteride or minoxidil, and, in appropriate cases, FUE hair transplant are planned together. Any clinic marketing mesotherapy as a complete solution to hair loss is misleading patients.

3) Body — Localised Mesotherapy (Cellulite / Localised Fat)

Applied to areas such as the outer thighs, buttocks, lower abdomen and backs of the upper arms. The cocktail contains substances claimed to stimulate fat cell metabolism (phosphatidylcholine, L-carnitine, caffeine). Its effect is limited and honesty is essential: cellulite is a structural connective tissue pathology. Reducing significant localised fat through mesotherapy alone is not achievable. Body mesotherapy is only meaningful as a supportive treatment alongside diet, exercise and body composition analysis. Do not take seriously any claims of "non-surgical liposuction" for body mesotherapy — that description does a disservice both to surgical liposuction and to the realistic expectations of mesotherapy itself.

Your first appointment can take place in person at our clinic or online via WhatsApp or Zoom. Topics we cover:

• Concern and goal: For the face — loss of luminosity, fine lines, pore visibility, uneven skin tone. For hair — which area is affected, how long it has been shedding, family history, previous treatments. For the body — target area, weight and nutritional status, exercise routine.
• Medical history: Pregnancy or breastfeeding status, active skin infection, autoimmune conditions (lupus, scleroderma), use of anticoagulants, allergy history (particularly sensitivity to procaine or lidocaine), previous mesotherapy or filler, history of cancer, thyroid status.
• Standardised photography: For the face — frontal, three-quarter and full profile views under standardised lighting. For hair mesotherapy — follicle density is measured with a dermatoscopy device. For body — photographs and circumference measurements of the target area are taken. Without this baseline it is impossible to objectively assess progress at session four.
• Realistic expectations: What mesotherapy can and cannot achieve is explained clearly. We clarify the difference from filler to avoid confusion; for hair, we emphasise that mesotherapy is one component of a multi-modal approach; for the body, its supportive role is made clear.

At the end of the consultation, the number of sessions, interval, cocktail to be used, indicative cost and the expected timeline for visible change are shared with you in writing. "Mesotherapy is not appropriate for you" is a valid outcome of a consultation — for instance, a patient who is a clear candidate for hair transplant will be directed first to surgical planning rather than mesotherapy.

Before your appointment day, there are things you need to know:

• Seven days before the procedure, aspirin, ibuprofen and other NSAIDs, fish oil, high-dose vitamin E and ginkgo biloba should be discontinued with your doctor's approval. Patients on prescribed anticoagulants (warfarin, clopidogrel, NOACs) should not stop their medication; risk is managed at the planning stage accordingly.
• 24 hours before, alcohol should be avoided.
• On the day, the treatment area should be clean and free of creams; make-up on the face is removed at the clinic.

At the clinic:

• The skin is cleansed and prepared with antiseptic.
• Topical anaesthetic cream is applied to the area for 15–20 minutes. This is standard for the face and scalp; optional for body applications.
• The needles used are very fine — 30–32 gauge. At Nis Clinic, injections are delivered using an MP Gun (mesotherapy gun); compared with manual needling, depth is more consistent, dosage more standardised, session time is shorter and discomfort perception is lower. Manual technique may be added for specific areas in particular circumstances; this is confirmed at consultation.

The application itself takes 15–30 minutes, depending on the area and the technique chosen.

• Facial mesotherapy: 80–150 micro-injections across the forehead, cheekbones, cheeks, chin and, where indicated, the neck — approximately 0.02–0.05 ml of cocktail per point. Duration: 15–25 minutes.
• Hair mesotherapy: 60–120 injections at 1 cm intervals across areas of greatest thinning (crown, hairline, temporal zones) — approximately 0.05–0.1 ml per point. Duration: 10–20 minutes.
• Localised body: 20–80 injections depending on area size — approximately 0.3–0.5 ml per point. Duration: 20–30 minutes.

During the application a mild stinging sensation and occasional small areas of redness are normal. Small raised bumps (papules) may appear in the treated area for 30–60 minutes afterwards; these are a visible sign of the cocktail dispersing slowly into the tissue and resolve within a few hours.

A few practical guidelines for the first 24 hours after your session:

• Avoid make-up (face — 24 hours). This allows injection points to close fully and minimises infection risk.
• Do not rub the treated area; avoid saunas, hammams, steam rooms and prolonged hot showers.
• Strenuous exercise, sun exposure and sunbeds should be deferred for 24–48 hours.
• For hair mesotherapy, do not wash your hair on the day of treatment; wash the following day with lukewarm water and a mild shampoo.

You can return to desk-based work, meetings and normal social activities immediately after leaving the clinic. No dressings, bandages or medication are required.

Mesotherapy is not a procedure from which a result is expected in a single session. It is a cumulative protocol.

• Initial protocol: Typically 4–8 sessions, spaced one week to ten days apart. Facial biorevitalisation is generally 4–6 sessions; hair mesotherapy is typically 6–8 sessions. Localised body treatment is usually 6–10 sessions.
• Timeline for visible change: A noticeable difference should not be expected after the first two sessions. From sessions three to four onwards, patients and those close to them typically begin to notice "fresher skin" or "reduced shedding". The formal assessment takes place one month after the first protocol is complete, comparing outcome against the baseline photographs.
• Maintenance: Following the initial protocol, monthly maintenance sessions (face) or sessions every 6–8 weeks (hair) are recommended. Some patients do not require maintenance — skin quality is preserved and further protocols are not needed unless a new trigger arises. Individual metabolism, age, lifestyle, smoking and UV exposure all influence maintenance needs.
• Durability: The effect of facial biorevitalisation typically remains visible for 6–12 months after the first protocol; this varies with age and the area treated. In the 25–35 age range, the benefit tends to last longer; at 45 and above, fading without maintenance occurs more quickly. For hair mesotherapy, the density gained must be supported by continued underlying treatment (medication, PRP, lifestyle adjustments) to be maintained.

• Patients aged 25 and over seeking to prevent early skin ageing: No deep lines yet, but early signs of skin ageing are present — loss of luminosity, enlarged pores, fine lines. Facial biorevitalisation is a meaningful investment for this group.
• Patients with early signs of ageing who are not considering surgery: Those aged 35–55 whose skin quality needs support but who are not yet facelift candidates.
• Patients diagnosed with androgenetic alopecia for whom mesotherapy is planned as part of a multi-modal programme: Patients who, following microtrichological assessment, have a defined protocol combining medical treatment and/or PRP with mesotherapy.
• Patients with telogen effluvium (temporary shedding triggered by stress, post-partum or medical conditions): Once the underlying cause has been addressed, mesotherapy may usefully support the recovery phase.
• Patients with fine, weak hair structure seeking added volume.
• Patients who have achieved partial improvement through diet and exercise but have persistent cellulite or localised fat concerns: Provided they accept mesotherapy as a supportive treatment rather than a standalone solution.
• Patients in good general health with realistic expectations.

In the following situations, mesotherapy is not performed or requires specific assessment:

• Pregnancy: Contraindicated. Safety data for cocktail ingredients (particularly procaine, certain vitamins and growth factor analogues) during pregnancy is insufficient; treatment is deferred until after delivery.
• Breastfeeding: Contraindicated. Insufficient data on transfer into breast milk means treatment is not performed during the breastfeeding period.
• Active skin infection: In the presence of active acne lesions, herpes, bacterial or fungal infection in the treatment area, the procedure is deferred until the infection has resolved. A prophylactic antiviral is planned for patients with a history of recurrent herpes.
• Autoimmune conditions: In systemic conditions such as lupus, scleroderma and dermatomyositis, a cautious approach is taken. These are not absolute contraindications; a risk–benefit assessment is made in conjunction with the treating physician.
• Anticoagulant use: Aspirin, clopidogrel, warfarin and NOACs increase the risk of bruising. Medically necessary medications are not stopped; the risk is explained clearly to the patient and the procedure is planned accordingly.
• Known allergy to cocktail ingredients: Patients with sensitivity to procaine, lidocaine, certain vitamins or peptides require careful selection; a test dose is administered in cases of uncertainty.
• Uncontrolled diabetes or thyroid disease: An internal medicine assessment is required first.
• Patients undergoing cancer treatment or immunosuppressive therapy: Not performed without approval from the treating oncologist or haematologist.
• Patients with a tendency to keloid scarring: Carefully assessed; there is a risk of excessive healing at injection sites.
• Body dysmorphic tendency: We decline to treat patients who present with an endless cycle of revision requests.
• Under 18: Not performed for cosmetic purposes.

Telling a patient "this is not right for you" is not a lost referral for us — it is a medical responsibility.

Mesotherapy is sometimes marketed as a "harmless procedure performed with a fine needle" — but sub-dermal injection is, above all, an exercise in anatomy. The vascular map of the face, nerve pathways, layers of the mimetic muscles and safe injection planes are the foundation of plastic surgery discipline. Op. Dr. İbrahim Meyzin is a Specialist in Plastic, Reconstructive and Aesthetic Surgery, and a full member of the Cyprus Turkish Medical Association (CTMA), Registration No. 969.

Mesotherapy is delivered at a depth of 1–4 mm below the skin. Even at that depth there are facial arteries, facial veins, sensory nerve branches and zones that must never be entered. The anatomical map for facial mesotherapy differs significantly from that for the scalp. Dr. Meyzin performs all injections personally; the model of "aesthetician operates, doctor supervises" is not practised at Nis Clinic.

Full doctor profile: Op. Dr. İbrahim Meyzin

The most common weakness in the mesotherapy market is that patients do not know what is being injected into them. Phrases such as "special blend", "clinic formula" and "exclusive cocktail" move patients away from transparency. Our standard at Nis Clinic:

• All cocktail ampoules used are CE-marked, with the manufacturer's label and batch number clearly readable.
• On the day of treatment, the patient is shown which product is being used, its full composition and its expiry date.
• For patients who request it, the product barcode is added to their patient file.
• The protocol is provided in writing; number of sessions, interval, dosage and indicative cost are confirmed at consultation — and if these change, the reason is shared.
• When the standard 4–8 session protocol is modified (e.g. a maintenance plan or an additional session is recommended), a clear rationale is given.

This transparency is not a marketing tool — it is a clinical standard.

Mesotherapy pricing varies according to indication (face, hair, body), number of sessions, the brand of cocktail used and the size of the treatment area. Approximate ranges at Nis Clinic:

We deliberately avoid quoting a fixed package price for localised body mesotherapy — because recommending a package without a realistic conversation with the patient about how many sessions are appropriate, and for which areas, would not be ethical. The effect of cellulite mesotherapy is limited; it is important to discuss expectations honestly before a patient commits to a course of ten sessions.

Price is confirmed after consultation; all packages include the standard number of sessions, cocktail products and review appointments. There are no hidden charges. The brand, batch number and expiry date of the product used are shown on the day of treatment.

Combination opportunity: Mesotherapy is frequently considered alongside botulinum toxin and dermal filler within the same treatment plan; the three work by different mechanisms and, when intelligently combined, the results complement one another. For hair loss, PRP and, in appropriate cases, FUE hair transplant can be planned alongside mesotherapy. International patients can enquire about accommodation and transfers through our medical tourism package. For appointments or questions, please visit our contact page or request a consultation directly.