What Is Hair PRP and How Does It Work?
PRP is an autologous plasma fraction separated from the patient's own blood by centrifuge. It contains 3–5 times the platelet concentration of whole blood. Platelets are the primary carriers of tissue-repair signals. When activated by injury or a stimulus, they release the growth factor proteins stored within them: PDGF, VEGF, EGF, TGF-β, IGF-1, FGF. These proteins are the molecular instructions that trigger cell proliferation, new blood vessel formation and tissue renewal.
In the scalp, this biological signal is directed at dermal papilla cells and the follicle stem-cell niche. The way PRP acts on hair can be summarised in three main mechanisms:
- Dermal papilla activation. The dermal papilla — the follicle's "control centre" — extends the anagen (growth) phase when stimulated by PDGF and IGF-1.
- Increased vascularisation. VEGF action densifies the capillary network around each follicle, improving its nutritional supply.
- Slowing of follicle miniaturisation. In androgenetic alopecia, follicles gradually shrink; growth factor support reduces the pace of this process.
PRP does not regenerate lost follicles; no new hair emerges from a follicle niche that has fully closed. Its role is to support follicles that have begun to miniaturise but are still active. This biological reality defines both who will benefit from the treatment and who will not.
Is Hair PRP the Same as Facial PRP?
They share the same biological principle — in both, a platelet concentrate prepared from the patient's own blood is used, and the same growth factors are at work. However, the application technique and patient selection are markedly different, which is why we have two separate pages and two separate protocols.
| Parameter | Hair PRP | Facial PRP |
|---|---|---|
| Injection depth | Dermis + subcutaneous (follicle-targeted) | Superficial to mid-dermis (fibroblast-targeted) |
| Volume per session | 4–6 mL across the scalp | 3–4 mL across the face |
| Injection pattern | Grid pattern — micro-injections approx. 1 cm apart | Mesotherapy grid or microneedling |
| Target cell | Dermal papilla + follicle stem cell | Dermal fibroblast |
| Starter protocol | 3 sessions, 4 weeks apart | 3–4 sessions, 4 weeks apart |
| Maintenance | Booster every 3–6 months | Booster every 6–12 months |
| Standalone efficacy | Limited — medication combination recommended | Often sufficient as a standalone |
Hair PRP differs from facial PRP most clearly in depth and pattern. Working at the dermis–subcutaneous boundary is necessary to target the follicle in the scalp; for the face, a shallower entry into the fibroblast layer is used. This difference shapes everything from needle depth adjustment to injection spacing.
In short: Facial PRP is a skin-renewal treatment; hair PRP is a hair-loss management treatment. We apply the same technology to two different clinical problems.
Evidence Base and Its Limits
Hair PRP occupies a position in the clinical literature as a treatment for androgenetic alopecia with promising but limited evidence. Published meta-analyses report measurable increases in hair density and shaft diameter in most patients, along with a reduction in the rate of shedding. That said:
- Response is not universal. Approximately 60–70% of patients show a meaningful response; in 30–40% no appreciable change is observed.
- Magnitude of response varies between individuals. One patient may see dramatic thickening; another may experience only a stabilisation of shedding.
- Protocol standardisation is still evolving. PRP kit type, platelet concentration ratio, activation method (CaCl₂, etc.) and session frequency differ between clinics, making cross-study comparisons difficult.
- PRP alone is generally insufficient. The strongest evidence comes from protocols in which PRP is used in combination with established androgenetic alopecia medications such as minoxidil or finasteride.
To answer the question "does hair PRP work?" concisely: "yes, in most suitable candidates — but conditionally, and better in combination." The question "will it bring my hair back?" has a different answer: "no — but it can support the quality and longevity of the hair you currently have."
The Hair PRP Process at Nis Clinic
Hair PRP is a treatment chain that runs from the blood draw through to monitoring new hair growth. We approach the process at Nis Clinic in five stages.
Consultation — Hair Loss Assessment
Before recommending PRP, we need to establish the type, stage and cause of your hair loss. Consultations can be held in person at our clinic or online via WhatsApp or Zoom. The assessment covers:
- Shedding pattern: Staged using the Norwood scale (male) or Ludwig scale (female). PRP produces its best responses at early to moderate stages (Norwood II–IV, Ludwig I–II).
- Type of loss: Is this androgenetic alopecia, telogen effluvium (diffuse shedding driven by stress, postpartum change, medication, anaemia), or alopecia areata? Each type responds differently.
- Duration and pace: How long has the shedding been going on? Is it active and progressing rapidly, or stable?
- Family history: Maternal and paternal history of hair loss.
- Medication and treatment history: Are you using minoxidil, finasteride or dutasteride? For how long? Have you had a previous hair transplant?
- Medical history: Thyroid disease, anaemia, PCOS, autoimmune conditions, uncontrolled diabetes? Use of anticoagulants?
- Donor area status: Could a hair transplant become necessary in the future? What is your donor capacity?
- Your goal: Is your aim to stop shedding, strengthen the hair you have, achieve thickening, or "get your hair back"? The last expectation is not achievable, and we discuss this openly at consultation.
At the end of the consultation, the recommended protocol (PRP alone, PRP + minoxidil, PRP + finasteride, PRP + hair transplant), the planned number of sessions and an indicative price are all shared with you in writing. If we do not believe PRP is right for you, we will say so without pressure. This consultation is a medical assessment, not a sales meeting.
Blood Draw and Centrifuge — 15–20 Minutes
The session-day protocol is as follows:
- Blood draw: A routine venous blood draw from your arm collects 20–30 mL of blood (hair PRP requires a slightly larger volume than facial PRP, because the scalp is a broader area with more injection points) into a CE-marked, single-use, closed-system PRP kit tube containing an anticoagulant and a separating gel.
- Centrifuge: The tube is spun in a calibrated medical centrifuge for 10–15 minutes at the revolutions and duration specified by the kit manufacturer. The blood separates into three layers: red blood cells (bottom), buffy coat (platelet-rich middle), and plasma (top).
- PRP extraction: The platelet-rich middle layer and the lower portion of the plasma are drawn into a sterile syringe. A typical session yields 4–6 mL of ready-to-use PRP.
- Optional activation: Some protocols use calcium chloride to activate the platelets before injection. This step is applied according to clinical preference; the comparative efficacy of activated versus non-activated PRP continues to be debated in the literature.
The entire process takes place in the same clinic room, without interruption. Your blood and PRP are never exchanged with another patient's. The kit batch number and expiry date are recorded; we can share these with you on request.
Injection — Grid Pattern, 30–45 Minutes
The application technique is where hair PRP differs most noticeably from facial PRP. Injections into the scalp follow a grid pattern:
- Skin preparation: The scalp is cleaned with an antiseptic. If you prefer a topical anaesthetic cream or cooling spray, this is applied for 15–20 minutes beforehand; a significant proportion of patients tolerate the procedure without any anaesthesia.
- Grid planning: In the affected areas, a grid of approximately 1 cm intervals is mapped out. For male-pattern alopecia, the fronto-temporal recession and vertex are targeted; for female-pattern loss, the central parting line is the focus.
- Micro-injection — MP Gun (automatic mesotherapy device): At Nis Clinic, hair PRP injections are administered using an MP Gun rather than a manual needle. The MP Gun positions a 30-gauge fine-tip needle at a fixed depth and delivers a standardised dose (0.05–0.1 mL per pulse), achieving a more homogeneous distribution and a shorter session duration than manual injection. From the patient's perspective, the advantage is consistent, rapid delivery rather than individual manual insertions; perceived discomfort is also lower. A typical session covers 40–80 grid points.
- Microneedling combination (optional): For some patients, a combined protocol using a dermaroller (microneedling) is recommended. Microneedling creates controlled micro-channels in the scalp, enhancing PRP penetration and mechanically amplifying the collagen and growth-factor response. This combination is sometimes called "vampire scalp" in popular media; in the clinical literature, the signal for PRP combined with microneedling is particularly positive for androgenetic alopecia. Related page: dermaroller (scalp microneedling).
The total session duration — including blood draw, centrifuge, anaesthesia and injection — is approximately 60–75 minutes. The procedure is carried out in a seated position; patients typically listen to music or watch television. You can return home around 30 minutes after the session ends.
Session Protocol and Monitoring Progress
Hair PRP is not a single-session treatment; it is a protocol-based therapy.
Starter protocol:
- 3 sessions, 4 weeks apart. The first three sessions initiate dermal papilla activation; the four-week interval allows adequate response development. More frequent sessions do not produce faster results.
- In some patients (where response is weak or androgenetic alopecia is at a more advanced stage), the starter phase may be extended to 4–6 sessions.
Maintenance:
- After the first three sessions, a booster session every 3–6 months is recommended. The interval is determined by the observed response and the underlying condition.
- Because androgenetic alopecia is a progressive condition, maintenance sessions are performed not to achieve a lasting outcome but to preserve existing gains.
Hair transplant combination protocol:
- Pre-operative: 1–2 PRP sessions before a hair transplant support follicle quality in the donor area and create a favourable biological environment for post-operative graft survival.
- Post-operative: 3 PRP sessions after a hair transplant (month 1, month 3, month 6) can improve graft survival, reduce the intensity of shock loss, and support the growth rate of transplanted follicles. We regularly recommend this combination after FUE and DHI procedures; further detail is available on the FUE hair transplant and DHI hair transplant pages.
Response timeline:
- Months 1–2: Some patients report that their hair looks more vibrant in this early period. This change is partly attributable to the trichological transition (telogen to anagen shift) and may be subjective.
- Months 3–6: The window in which true PRP response matures. Reduced shedding, thickening of the hair shaft and emergence of fine new hairs are typically noticed in this period.
- Months 6–12: Peak response. In patients who respond, a measurable increase in hair density is observed.
- After month 12: Without maintenance sessions, the effect gradually diminishes and shedding returns to its underlying course.
We monitor progress using photographs and trichoscopy. Standardised photographs taken before treatment and at months 3, 6 and 12 — under identical conditions (same lighting, same angle) — are the only reliable way to measure change objectively. In an area where subjective impression in the mirror can mislead, photographic comparison is non-negotiable.
Who Is a Suitable Candidate — and Who Is Not?
Who will respond to hair PRP is perhaps the section of this page that calls for the most honest conversation. The message "it helps with any kind of hair loss" may be commercially appealing, but it is not medically accurate.
Suitable Candidates and Indications
- Androgenetic alopecia (early to moderate stage): The group that responds best. In male patients at Norwood II–IV and female patients at Ludwig I–II, the follicle is still active and miniaturisation can be slowed. PRP creates real value at this stage.
- Telogen effluvium: In diffuse shedding triggered by stress, the postpartum period, severe caloric restriction, anaemia, thyroid dysfunction or febrile illness, PRP may accelerate hair regrowth once the underlying cause has been addressed. The primary intervention is resolving the cause; PRP plays a supportive role.
- Alopecia areata (small plaques): In small, well-defined plaques it may be considered as an adjuvant alongside intralesional corticosteroid injections. For widespread or rapidly progressive alopecia areata, dermatological treatment takes priority.
- Pre-operative preparation for hair transplant: 1–2 sessions are recommended to support follicle quality in the donor area and improve post-operative graft survival.
- Post-operative adjuvant after hair transplant: A 3-session post-operative protocol can support graft survival, ease the shock-loss phase and enhance the growth rate of transplanted hair.
- Post-menopausal female-pattern hair thinning: In hormonally driven hair thinning, PRP may be considered as a supportive option alongside an endocrine assessment.
- Combined treatment with minoxidil or finasteride: This is PRP's most effective mode of use. Combining it with these medications layers the chemical stimulus of the drug on top of the biological stimulus of PRP, producing a more marked response than either treatment alone.
Contraindications and Situations Requiring Caution
In the following circumstances, PRP is not administered or requires a specialist assessment:
- Advanced androgenetic alopecia (Norwood V–VII, Ludwig III): At these stages, follicle miniaturisation is largely complete or the follicle niches have closed. If no viable follicles remain for PRP to target, the treatment serves no useful purpose. For these patients, the appropriate path is a hair transplant assessment — if donor capacity is adequate, FUE or DHI is planned. Where donor capacity is insufficient, transplantation is also limited; an honest conversation about realistic expectations is essential.
- Pregnancy and breastfeeding: A relative contraindication. The procedure is deferred during pregnancy and breastfeeding in accordance with the principle of avoiding elective cosmetic procedures and due to insufficient clinical safety data.
- Thrombocytopaenia and coagulopathy: Conditions causing a low platelet count (ITP, bone marrow suppression) directly reduce the quality of the source material for PRP. Clotting disorders (haemophilia, von Willebrand disease) are not compatible with the procedure.
- Active cancer treatment: PRP is not administered in patients undergoing chemotherapy or radiotherapy. Following completion of chemotherapy, hair-loss-related PRP may be considered once oncologist approval has been obtained.
- Active scalp infection: In the presence of folliculitis, a seborrhoeic dermatitis flare, psoriasis plaque activation, or bacterial or fungal infection, the affected area is excluded or the procedure is deferred.
- Systemic infection and sepsis: PRP is not administered in the presence of active systemic infection.
- Anticoagulant and antiplatelet therapy: The decision to pause anticoagulant medication in patients on blood thinners is made in coordination with the prescribing physician; it should be remembered that impaired platelet function reduces PRP quality. Aspirin, NSAIDs (ibuprofen, naproxen), fish oil and high-dose vitamin E are stopped 7 days before the procedure with the physician's approval.
- Under 18 years of age: Not administered for cosmetic purposes.
- Scarring alopecia (lichen planopilaris, frontal fibrosing alopecia, discoid lupus): Follicular destruction is irreversible; PRP is ineffective. Dermatological treatment takes priority.
- Unrealistic expectations: PRP is not the right answer for a patient who arrives expecting their hair to be fully restored. It is not our clinic's practice to offer a promise we cannot biologically fulfil.
Telling someone "this is not right for you" is not lost business for us — it is a necessary decision in the interest of genuine treatment value and patient safety. What is medically correct is not always commercially attractive.
Why Nis Clinic? Hair Transplant Integration and Pricing
Hair PRP is offered at many centres in Northern Cyprus (TRNC); however, the protocol standard, patient selection and degree of integration with hair transplant procedures create a meaningful difference. Nis Clinic's distinction in hair PRP can be considered across three dimensions.
Standardised Protocol Under Plastic Surgery Supervision
Hair PRP is listed at many beauty centres as an easy revenue stream. What distinguishes one clinic from another is not the signage but the underlying protocol:
- Kit standard: We use CE-marked, closed-system, single-use PRP kits. Each patient's kit is individual; the batch number is recorded.
- Calibrated centrifuge: A medical centrifuge with tracked calibration, operated at the parameters specified by the kit manufacturer. Hair PRP is not prepared using a general-purpose or uncalibrated device.
- Sterile field: Skin antiseptic, sterile gloves and single-use equipment throughout. Blood draw and injection take place in the same room, without interruption.
- Dr. Meyzin's oversight: The procedure is conducted by Op. Dr. İbrahim Meyzin personally or, under his direct supervision, by the experienced clinical team. His plastic surgery specialist training — encompassing scalp anatomy, vascular mapping, follicle dynamics and surgical healing — provides a decisive advantage when using PRP as a hair transplant adjuvant.
- Trichoscopy and photographic monitoring: We maintain a photographic archive for each patient taken under standardised conditions at baseline and at each review point. Objective comparison is the only reliable way to measure response; in an area where subjective impression misleads, transparent follow-up is non-negotiable.
Relationship With Hair Transplantation — When Is PRP the Solution, When Is It an Adjuvant?
Hair PRP and hair transplantation are two distinct treatments that intersect at different points in the same patient journey. The relationship can be summarised in three scenarios:
- If you are not a transplant candidate (early to moderate hair loss): PRP, used alone or in combination with medication, can serve as a valuable protective treatment. The goal is to stabilise shedding and support existing follicles.
- If you are a transplant candidate: PRP plays a role as a pre-operative and post-operative adjuvant. 1–2 sessions before surgery prepare the donor area; 3 sessions after surgery support graft survival. We can integrate this combination into both FUE and DHI packages.
- Advanced hair loss with insufficient donor capacity: Neither PRP nor hair transplantation, alone or together, can offer a complete solution. In this scenario, our preference is honest conversation: is it limited-goal transplantation + long-term medication + maintenance PRP, a hairpiece, or acceptance? The answer is built together, according to the patient's priorities.
There is no single correct answer to "hair PRP or hair transplant?" The right question is: which combination of treatments suits your pattern of loss, your donor capacity and your goals? We reach that decision together at consultation.
Transparent Pricing
Hair PRP prices at Nis Clinic are determined by the treatment area, package structure and combination protocol. We do not negotiate per unit; our pricing is transparent at the session and package level.
Approximate price ranges (Nis Clinic — 2026):
| Treatment | Approximate Price |
|---|---|
| Hair PRP (single session) | approx. €120 |
| Hair PRP 3-session starter package | approx. €320 |
| PRP + microneedling (vampire scalp) per session | approx. €170 |
| Pre-op 1 session + post-op 3 sessions (transplant combo) | Integrated with hair transplant package |
| Maintenance booster session (every 3–6 months) | approx. €120 |
The price varies according to the size of the target area (a small vertex zone versus the full hairline), the kit used, and whether microneedling is added. A package discount does not mean a reduction in standards — the protocol is identical in every session.
Hair PRP is a single-day, outpatient procedure and does not require a medical tourism package. Patients attending as part of a hair transplant package have pre- and post-operative PRP sessions planned within that package. Patients travelling from Türkiye or the United Kingdom for a combined treatment and holiday can be seen for consultation and treatment at our Kyrenia location.
Note: When medication such as minoxidil and/or finasteride is recommended to maximise the efficacy of hair PRP, medication costs are not included in the package. A prescription is written after consultation. The combined effect of medication and PRP is markedly greater than PRP alone — this is a factor worth considering when making your decision.
Frequently Asked Questions
How is hair PRP performed? What happens from blood draw to injection?
What is the difference between hair PRP and facial PRP?
Will hair PRP bring my hair back?
How many hair PRP sessions are needed?
When will I see results from hair PRP?
Is hair PRP sufficient on its own, or is medication essential?
Who is hair PRP not suitable for?
Is PRP before and after a hair transplant essential?
Is a hair PRP session painful? What are the side effects?
How much does hair PRP cost in North Cyprus?
Which is more effective — hair PRP or hair mesotherapy?
Is the effect of hair PRP permanent? Will shedding return if I stop the sessions?
Medical Review
Op. Dr. İbrahim MeyzinSpecialist in Plastic, Reconstructive and Aesthetic Surgery, Cyprus Turkish Medical Association (CTMA), Registration No. 969
Specialist in Plastic, Reconstructive and Aesthetic Surgery, Cyprus Turkish Medical Association (CTMA), Registration No. 969
Last reviewed: